ncRNA name | hsa-miR-18b |
ncRNA Category | miRNA |
Disease name | diabetic retinopathy (DR) |
Species | Homo sapiens |
Tissues/Cell_line | human retinal endothelial cells (HRECs) |
Methods | transfection, qRT-PCR, immunocytochemistry, luciferase reporter assay, Western blot, ELISA |
Expression pattern | down-regulated |
Functional description | miR-18b exerted its function on VEGF synthesis and cell proliferation by suppressing the IGF-1/insulin growth factor-1 receptor (IGF1R) pathway, consequently inhibiting the downstream phosphorylation of Akt, MEK, and ERK. |
PubMed ID | 26851511 |
Year | 2016 |
Title | MiR-18b suppresses high-glucose-induced proliferation in HRECs by targeting IGF-1/IGF1R signaling pathways. |
Drug-related ncRNA | NO |
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